Search results for "Causal link"

Host-manipulation by parasites with complex life cycles: adaptive or not?

2010

7 pages; International audience; The effect of host manipulation by parasites on trophic transmission to final hosts remains unclear. The transmission benefits gained by manipulative parasites are difficult to assess, and evidence for a causal link between manipulation and trophic transmission is missing. In addition, infected intermediate hosts can also be more vulnerable to predation by nonhosts, whereas recent theoretical advances indicate that the evolution of host manipulation does not require increased specificity in trophic transmission. We propose that a deeper consideration of the evolution of complex life cycles in helminth parasites might provide a different perspective on the ev…

Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits

2020

International audience; Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could underlie reward-processing deficits. We show that reduced n-3 PUFA biostatus in mice leads to selective motivational impairments. Electrophysiological recordings revealed increased collateral inhibition of dopamine D2 receptor-expressing medium spiny neurons (D2-MSNs) onto dopamine D1 receptor-expressing MSNs in the nucleus accumbens, a main brain regio…

Examining bi-directionality between Fear of Missing Out and problematic smartphone use. A two-wave panel study among adolescents.

2020

Abstract Background In recent years, the Fear of Missing Out (FoMO) construct has been the object of growing attention in digital technology research with previous studies finding support for the relationship between FoMO and problematic smartphone use (PSU) among adolescents and young adults. However, no previous studies clarified the causal link between FoMO and PSU using a longitudinal design. Methods An auto-regressive, cross-lagged panel design was tested by using a longitudinal dataset with two waves of data collection (T0 and T1, one year apart). Participants included two hundred and forty-two adolescents (109 males and 133 females), with a mean age of 14.16 years, who filled out the…

The Link Between Local Recurrence and Distant Metastases in Patients With Rectal Cancer.

2019

BACKGROUND/AIM The relationships between local recurrence (LR), the development of distant metastases (DM) and prognosis in patients with rectal cancer remain unclear. PATIENTS AND METHODS In 606 patients who underwent curative resection, the role of LR was assessed retrospectively by time-dependent multivariate Cox models with inverse probability of treatment weighting taking into account competing risks. RESULTS Patients with LR had more DM than patients without LR (49/79, 62% vs. 86/524, 16.4%; p<0.001); 37% of LR-associated DM developed before or at LR, 63% after diagnosis of LR. Fifty-five percent of patients without DM at diagnosis of LR later developed DM. In these patients, the inci…

Bovine spongiform encephalopathy and Creutzfeldt-Jakob disease: facts and uncertainties underlying the causal link between animal and human diseases

2004

Following an outbreak of bovine spongiform encephalopathy (BSE) in dairy cows in the United Kingdom (UK), 153 definite and probable human cases of new variant Creutzfeldt-Jakob disease (nvCJD) have been reported, almost exclusively in the UK. Although exposure to the BSE agent is the most plausible interpretation for the occurrence of nvCJD, the causal link between the BSE prion and nvCJD is still debated. This review discusses the pros and cons of nvCJD as a separate nosographic entity, the scientific basis for a correlation between BSE and nvCJD, the validity of the current diagnostic criteria for CJD and nvCJD, the contribution of epidemiology to the detection of a causal relation betwee…

Medical Malpractice: the Italian Experience

2012

Difetto del nesso causale e manifesta insussistenza del fatto nel licenziamento per giustificato motivo oggettivo

2021

Con la sentenza n. 16253/2020 la Suprema Corte ha affermato che l’assenza di nesso causale tra la cessazione di un appalto e il licenziamento del lavoratore integra un’ipotesi di manifesta insussistenza del fatto posto alla base del licenziamento - con conseguente applicabilità della tutela reintegratoria attenuta di cui all’art. 18, comma 5, della legge n. 300/1970 - non riconducibile, pertanto, agli altri casi in cui il giudice dichiara risolto il rapporto concedendo la sola tutela indennitaria forte (da dodici a ventiquattro mensilità).

Ba/Ca ratios in shells of Arctica islandica —Potential environmental proxy and crossdating tool

2017

Abstract Ba/Ca shell time-series of marine bivalves typically show flat background levels which are interrupted by erratic sharp peaks. Evidence from the literature indicates that background Ba/Ca shell ratios broadly reflect salinity conditions. However, the causes for the Ba/Ca shell peaks are still controversial and widely debated although many researchers link these changes to primary productivity, freshwater input or spawning events. The most striking feature is that the Ba/Ca shell peaks are highly synchronous in contemporaneous specimens from the same population. For the first time, we studied Ba/Ca shell in mature and ontogenetically old (up to 251 year-old) specimens of the long-li…